Tc-gallic-gold nanoparticles as a new imaging platform for tumor targeting.

Appl Radiat Isot

Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt. Electronic address:

Published: October 2020

Early and accurate detection of tumor assists in identifying more effective therapies. Gold nanoparticles (GNPs) were synthesized by green synthesis method using gallic acid (GA) then characterized and labeled with technetium-99m. This new platform was biologically evaluated in both normal and solid tumor bearing mice. The in-vivo study of [Tc]Tc-gallic-GNPs via both I.V. and I.T injecton showed a high accumulation in tumor site. As a result, [Tc]Tc-gallic-GNPs can be afforded as a potential nano-platform for tumor imaging.

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Source
http://dx.doi.org/10.1016/j.apradiso.2020.109269DOI Listing

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