Hormonal contraceptives contain an Estrogen and/or a Progestin, which are the substrates of the CYP3A4 enzyme and the drugs inducing the CYP3A4 enzyme can decrease the plasma concentrations and thereby therapeutic efficacy of Hormonal contraceptives resulting in unintended pregnancy. Moreover, the hormonal contraceptives associated risk of thrombotic events are further exacerbated by the simultaneous administration of drugs like Tranexamic acid and tobacco smoke. Therefore, while prescribing hormonal contraception and other drugs to women, drug interactions should always be considered because there could be a possible contraceptive failure or other adverse drug effects. This article provides a summary of guidance to healthcare professionals such as prescribers and pharmacists on pharmacokinetic based interactions between hormonal contraception and other drugs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1871530320666200820092534 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The major phytocannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), affect the function of CatSper calcium channels in human sperm.
Hum Reprod
March 2025
Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Study Question: Do the main psychoactive phytocannabinoid delta-9-tetrahydrocannabinol (THC) and its non-psychoactive analog cannabidiol (CBD) affect human sperm function?
Summary Answer: THC and CBD affect the sperm-specific Ca2+ channel CatSper, suppress activation of the channel by progesterone (P4) and prostaglandin E1 (PGE1), and THC also alters human sperm function in vitro.
What Is Known Already: Marijuana (Cannabis sativa) is one of the most commonly used recreational drugs worldwide. Although the effects of phytocannabinoids on semen parameters have been studied, there is no evidence of a direct impact of THC and CBD on human sperm.
Comparing 17β-estradiol and progesterone concentrations in young, physically active females: Insights from plasma versus serum analysis.
Exp Physiol
March 2025
Women in Sport Research and Innovation Hub, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Serum measurements of 17β-estradiol and progesterone are widely used to verify menstrual cycle status and confirm contraceptive use, often through commercially available immunoassay kits. However, no studies have investigated whether blood collection tube chemistries influence hormone concentrations in young females, despite assays permitting the use of different biofluids with similar reference ranges. In this study, venous blood was sampled from physically active females (n = 25) using Ethylenediaminetetraacetic acid (EDTA) and serum vacutainers, and 17β-estradiol and progesterone concentrations were measured using competitive immunoenzymatic assays.
View Article and Find Full Text PDFContraceptive use, both oral and parenteral, is associated with increased arterial stiffness in young healthy women.
Endocrine
March 2025
Department of Clinical Diagnostics, School of Health and Welfare, Jönköping University, Jönköping, Sweden.
Purpose: Previous studies on the impact on arterial health of contraceptive use, or across the menstrual phases, have yielded differing results. Furthermore, there is little research on the differences based on the delivery method of the contraceptive, oral vs parenteral contraceptives. In this study, we examined arterial health using three different physiological measures of arterial function and structure in contraceptive users and non-users.
View Article and Find Full Text PDFEffects of Female Sex Hormone Therapy on Nasal Mucosa.
Indian J Otolaryngol Head Neck Surg
February 2025
I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Women worldwide commonly use combined oral contraceptives (COCs) and hormone replacement therapy(HRT). Nevertheless, there is still ambiguity regarding the possible influence of these hormone therapy on the nasal mucosa. A systematic review was performed according to PRISMA guidelines.
View Article and Find Full Text PDFInternational evidence-based recommendations for polycystic ovary syndrome in adolescents.
BMC Med
March 2025
Monash Centre for Health Research and Implementation, School of Clinical Sciences, Monash University, Clayton, VIC, 3168, Australia.
Background: During adolescence, accurate diagnostic criteria and/or identification of adolescents "at risk" of polycystic ovary syndrome (PCOS) are critical to establish appropriate screening, treatment, and lifelong health plans. The 2023 International Evidence-Based Guideline for PCOS aimed to provide the most up-to-date evidence-based recommendations to improve health outcomes for individuals with PCOS, emphasizing accurate and timely diagnosis of PCOS from adolescence.
Methods: The best practice methods following the Appraisal of Guidelines for Research and Evaluation (AGREE-II) criteria were applied.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!