Column water vapor (CWV) is studied using data from the Dynamics of the Madden-Julian Oscillation (DYNAMO) field experiment. A distinctive moist mode in tropical CVW probability distributions motivates the work. The Lagrangian CWV tendency (LCT) leaves together the compensating tendencies from phase change and vertical advection, quantities which cannot be measured accurately by themselves, to emphasize their small residual, which governs evolution. The slope of LCT vs. CWV suggests that the combined effects of phase changes and vertical advection act as a robust positive feedback on CWV variations, while evaporation adds a broadscale positive tendency. Analyzed diabatic heating profiles become deeper and stronger as CWV increases. Stratiform heating is found to accompany Lagrangian drying at high CWV, but its association with deep convection makes the mean LCT positive at high CWV. Lower-tropospheric wind convergence is found in high-CVW airmasses, acting to shrink their area in time. When ECMWF heating profile indices and S-POL and TRMM radar data are binned jointly by CWV and LCT, bottom-heavy heating associated with shallow and congestus convection is found in columns transitioning through Lagrangian moistening into the humid, high-rainrate mode of the CWV distribution near 50-55mm, while non-raining columns and columns with widespread stratiform precipitation are preferentially associated with Lagrangian drying. Interpolated sounding-array data produce substantial errors in LCT budgets, because horizontal advection is inaccurate without satellite input to constrain horizontal gradients.
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http://dx.doi.org/10.1175/JAS-D-15-0243.1 | DOI Listing |
PLoS One
October 2024
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Objectives: Long-term exposure to air pollution has been associated with higher risk of cardiovascular mortality. Less is known about the association of air pollution with initial development of cardiovascular disease. Herein, the association between low-level exposure to air pollutants and subclinical carotid atherosclerosis in adults without known clinical cardiovascular disease was investigated.
View Article and Find Full Text PDFIdentifying the processes underlying community assembly and dynamics remains a central goal in ecology. Although much research has been devoted to analyzing how environments affect species diversity, fewer studies have resolved the link between the fundamental process of ecological selection and species diversity. It has been suggested that identifying ecological selection by estimating changes in community-weighted variance (CWV) and mean (CWM) of functional traits may help to identify more general rules of community assembly.
View Article and Find Full Text PDFAlzheimers Dement
November 2024
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Introduction: Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the associations between inflammatory biomarkers and MRI measures and to examine sex differences among the associations in the Framingham Heart Study.
View Article and Find Full Text PDFInt J Mol Sci
January 2024
Institute of Biological Information Processing IBI-7: Structural Biochemistry, Forschungszentrum Jülich, 52428 Jülich, Germany.
The arbovirus Chikungunya (CHIKV) is transmitted by mosquitoes in urban environments, and in humans, it triggers debilitating symptoms involving long-term complications, including arthritis and Guillain-Barré syndrome. The development of antiviral therapies is relevant, as no efficacious vaccine or drug has yet been approved for clinical application. As a detailed map of molecules underlying the viral infection can be obtained from the metabolome, we validated the metabolic signatures of Vero E6 cells prior to infection (CC), following CHIKV infection (CV) and also upon the inclusion of the nsP2 protease inhibitor wedelolactone (CWV), a coumestan which inhibits viral replication processes.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
August 2023
Saha Cardiovascular Research Center (N.A., C.-H.W., H.S., S.I., A.C.P., C.W., J.J.M., D.A.H., G.A.G., A.D., H.S.L.), University of Kentucky, Lexington.
Background: Angiotensinogen (AGT) is an essential component in the renin-angiotensin system. AGT has highly conserved sequences in the loop and β-sheet regions among species; however, their functions have not been studied.
Methods: Adeno-associated viral vector (AAV) serotype 2/8 encoding mouse AGT with mutations of conserved sequences in the loop (AAV.
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