AI Article Synopsis
- The study aimed to evaluate the effectiveness of cortex phellodendri compound fluid (CPCF) in treating diabetic foot ulcers (DFU) compared to the Kangfuxin solution (KFS).
- Conducted over four years, 720 patients were divided into an experimental group (CPCF) and a control group (KFS), with assessments of ulcer size, growth factor levels, treatment effectiveness, and adverse events after four weeks.
- Results showed CPCF significantly improved ulcer healing and growth factor levels without increasing adverse event rates, indicating it is a safe and effective treatment option for DFU.
Article Abstract
BACKGROUND The aim of this study was to analyze the clinical application of cortex phellodendri compound fluid (CPCF) in the treatment of diabetic foot ulcers. MATERIAL AND METHODS From January 2012 to December 2015, a total of 720 cases of diabetic foot ulcers (DFU) were randomly assigned into an experimental group (n=540) that was treated by CPCF and a control group (n=180) that was treated by a Kangfuxin solution (KFS). After 4 weeks of treatment, their ulcer area, serum growth factor, clinical total effective rate, and incidence of adverse events were assessed. RESULTS There were 720 patients who completed the trial. The experimental group was superior to the control group in reducing ulcer area, increasing growth factor content, and total effective rate (P<0.05). There was no significant difference in the adverse events rates between the 2 groups. CONCLUSIONS CPCF external treatment of diabetic foot ulcer can promote ulcer healing and increase the concentration of growth factors, and it is safe and reliable.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453754 | PMC |
| http://dx.doi.org/10.12659/MSM.923424 | DOI Listing |
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