Humans show striking limitations in information processing when multitasking yet can modify these limits with practice. Such limitations have been linked to a frontal-parietal network, but recent models of decision-making implicate a striatal-cortical network. We adjudicated these accounts by investigating the circuitry underpinning multitasking in 100 human individuals and the plasticity caused by practice. We observed that multitasking costs, and their practice-induced remediation, are best explained by modulations in information transfer between the striatum and the cortical areas that represent stimulus-response mappings. Specifically, our results support the view that multitasking stems at least in part from taxation in information sharing between the putamen and pre-supplementary motor area (pre-SMA). Moreover, we propose that modulations to information transfer between these two regions leads to practice-induced improvements in multitasking.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458802 | PMC |
| http://dx.doi.org/10.1523/ENEURO.0139-20.2020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The causal role of the subthalamic nucleus in the inhibitory network.
Ann N Y Acad Sci
August 2024
Neuroimaging Laboratory, Neurosciences Department, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
The neural network mediating successful response inhibition mainly includes right hemisphere activation of the pre-supplementary motor area, inferior frontal gyrus (IFG), subthalamic nucleus (STN), and caudate nucleus. However, the causal role of these regions in the inhibitory network is undefined. Five patients with Parkinson's disease were assessed prior to and after therapeutic thermal ablation of the right STN in two separate functional magnetic resonance imaging (fMRI) sessions while performing a stop-signal task.
View Article and Find Full Text PDFMapping Motor Cortical Network Excitability and Connectivity Changes in De Novo Parkinson's Disease.
Mov Disord
September 2024
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Background: Transcranial magnetic stimulation-electroencephalography (TMS-EEG) has demonstrated decreased excitability in the primary motor cortex (M1) and increased excitability in the pre-supplementary motor area (pre-SMA) in moderate-advanced Parkinson's disease (PD).
Objectives: The aim was to investigate whether these abnormalities are evident from the early stages of the disease, their behavioral correlates, and relationship to cortico-subcortical connections.
Methods: Twenty-eight early, drug-naive (de novo) PD patients and 28 healthy controls (HCs) underwent TMS-EEG to record TMS-evoked potentials (TEPs) from the primary motor cortex (M1) and the pre-SMA, kinematic recording of finger-tapping movements, and a 3T-MRI (magnetic resonance imaging) scan to obtain diffusion tensor imaging (DTI) reconstruction of white matter (WM) tracts connecting M1 to the ventral lateral anterior thalamic nucleus and pre-SMA to the anterior putamen.
Pre-supplementary Motor Cortex Mediates Learning Transfer from Perceptual to Motor Timing.
J Neurosci
February 2024
Instituto de Neurobiología, Querétaro 76230, México
When we intensively train a timing skill, such as learning to play the piano, we not only produce brain changes associated with task-specific learning but also improve our performance in other temporal behaviors that depend on these tuned neural resources. Since the neural basis of time learning and generalization is still unknown, we measured the changes in neural activity associated with the transfer of learning from perceptual to motor timing in a large sample of subjects ( = 65; 39 women). We found that intense training in an interval discrimination task increased the acuity of time perception in a group of subjects that also exhibited learning transfer, expressed as a reduction in inter-tap interval variability during an internally driven periodic motor task.
View Article and Find Full Text PDFAltered resting-state functional connectivity of medial frontal cortex in overweight individuals: Link to food-specific intentional inhibition and weight gain.
Behav Brain Res
September 2022
Faculty of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China. Electronic address:
Numerous findings from functional neuroimaging research suggest that overweight may be associated with alterations in reactive inhibition. However, there is a dearth of research investigating the functional connectivity that mediates intentional inhibition in overweight individuals. To explore this issue, 55 overweight and 45 normal-weight adults completed an assessment consisting of a resting-state functional magnetic resonance imaging scan, a behavioural task measuring food-specific intentional inhibition, and a 1-year longitudinal measurement of BMI change.
View Article and Find Full Text PDFAdvanced diffusion imaging to track progression in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Neuroimage Clin
May 2022
Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA; Department of Neurology and the Norman Fixel Institute for Neurological Diseases, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:
Advanced diffusion imaging which accounts for complex tissue properties, such as crossing fibers and extracellular fluid, may detect longitudinal changes in widespread pathology in atypical Parkinsonian syndromes. We implemented fixel-based analysis, Neurite Orientation and Density Imaging (NODDI), and free-water imaging in Parkinson's disease (PD), multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), and controls longitudinally over one year. Further, we used these three advanced diffusion imaging techniques to investigate longitudinal progression-related effects in key white matter tracts and gray matter regions in PD and two common atypical Parkinsonian disorders.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!