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Background: Type 2 Diabetes Mellitus (T2DM) is a significant public health burden. Emerging evidence links volatile organic compounds (VOCs), such as benzene to endocrine disruption and metabolic dysfunction. However, the effects of chronic environmentally relevant VOC exposures on metabolic health are still emerging.
View Article and Find Full Text PDFNovel technologies for the diagnosis of urinary tract infections.
J Clin Microbiol
January 2025
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Urinary tract infections (UTIs) impose a substantial burden on patient quality of life and urine testing accounts for the majority of workload in many clinical microbiology laboratories. Traditional UTI diagnosis relies on symptoms, urinalysis, and culture which are interpreted based on historical guidelines. This approach, while foundational, presents limitations, particularly in complex cases.
View Article and Find Full Text PDFA stress paradox: the dual role of the unfolded protein response in the placenta.
Front Endocrinol (Lausanne)
January 2025
Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
The placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic reticulum (ER), a dynamic organelle responsible for maintaining cellular protein and lipid synthesis and processing.
View Article and Find Full Text PDFSuboptimal refeeding compensates stunting in a mouse model of juvenile malnutrition.
J Nutr
January 2025
Institut de Génomique Fonctionnelle de Lyon, École Normale Supérieure de Lyon, CNRS UMR 5242, UCBL Lyon-1, F-69007 Lyon, France. Electronic address:
Background: Early postnatal life is a critical period of rapid growth in mammals, heavily reliant on adequate nutrition. Protein-energy malnutrition (PEM) during this window can lead to stunting and wasting, with lasting health consequences.
Objective: This study developed a mouse model of juvenile PEM to assess the effects of refeeding with various diets and interventions on growth recovery, including probiotic supplementation and suboptimal refeeding diets.
PFSH-Net: Parallel frequency-spatial hybrid network for segmentation of kidney stones in pre-contrast computed tomography images of dogs.
Comput Biol Med
January 2025
Division of Electronics and Information Engineering, College of Engineering, Jeonbuk National University, 567, Baekje-daero, Deokjin-gu, 54896, Jeonju, Republic of Korea. Electronic address:
Kidney stone is a common urological disease in dogs and can lead to serious complications such as pyelonephritis and kidney failure. However, manual diagnosis involves a lot of burdens on radiologists and may cause human errors due to fatigue. Automated methods using deep learning models have been explored to overcome this limitation.
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