Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41594-020-0486-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combating Tuberculosis via Restoring the Host Immune Capacity by Targeting Kinases and Phosphatases.
Int J Mol Sci
November 2024
Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Perth, WA 6102, Australia.
() is a remarkably versatile pathogen that possesses a unique ability to counteract the host's defence mechanisms to control the infection. Several mycobacterial protein kinases and phosphatases were found to play a key role in impeding phagosome maturation in macrophages and accordingly blocking the phagosome-lysosome fusion, therefore allowing the bacteria to survive. During phagocytosis, both and the host's phagocytic cells develop mechanisms to fight each other, resulting in pathogen elimination or survival.
View Article and Find Full Text PDFThe Chlamydia pneumoniae effector SemD exploits its host's endocytic machinery by structural and functional mimicry.
Nat Commun
August 2024
Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Functional Microbial Genomics, Düsseldorf, Germany.
To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the host-cell's plasma membrane and recruit several pivotal endocytic host proteins. Here, we present the high-resolution structure of an entry-related chlamydial effector protein, SemD. Co-crystallisation of SemD with its host binding partners demonstrates that SemD co-opts the Cdc42 binding site to activate the actin cytoskeleton regulator N-WASP, making active, GTP-bound Cdc42 superfluous.
View Article and Find Full Text PDFDeciphering the role of CD47 in cancer immunotherapy.
J Adv Res
September 2024
Tongji University Cancer Center, Shanghai Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address:
Article Synopsis
- Immunotherapy is a new way to treat cancer after methods like surgery and chemotherapy, and it includes therapies like CAR-T cells and immune checkpoint blockade.
- A key player in this treatment is a protein called CD47, which tells the immune system not to attack cancer cells by acting like a "don't eat me" signal.
- The review explains how targeting CD47 could help immunotherapy work better, but it also points out challenges like possible side effects from targeting CD47 because it's found on normal blood cells as well.
Marburg virus exploits the Rab11-mediated endocytic pathway in viral-particle production.
Microbiol Spectr
September 2024
National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.
Filoviruses produce viral particles with characteristic filamentous morphology. The major viral matrix protein, VP40, is trafficked to the plasma membrane and promotes viral particle formation and subsequent viral egress. In the present study, we assessed the role of the small GTPase Rab11-mediated endocytic pathway in Marburg virus (MARV) particle formation and budding.
View Article and Find Full Text PDFThe Roles of Endocytosis and Autophagy at the Cellular Level During Influenza Virus Infection: A Mini-Review.
Infect Drug Resist
July 2024
Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 40161, Indonesia.
Acute respiratory infections contribute to morbidity and mortality worldwide. The common cause of this deadly disease is a virus, and one of the most commonly found is the influenza virus. Influenza viruses have several capabilities in infection, including utilizing the host's machinery to survive within cells and replicate safely.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!