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Salivary proteomic profile of dogs with and without dental calculus. | LitMetric

AI Article Synopsis

  • The study investigates the saliva composition of dogs to understand proteins linked to oral health, specifically comparing those with and without dental calculus.
  • A total of 658 unique proteins were identified in saliva samples from 20 dogs, revealing distinct profiles for those with and without dental calculus.
  • Findings suggest that certain salivary proteins could serve as potential biomarkers for chronic periodontitis in dogs, highlighting the need for further research.

Article Abstract

Background: Dogs' saliva is a complex mixture of inorganic and organic constituents, rich in proteins. Therefore, knowing the saliva composition of these animals is extremely important to identify the presence of proteins that may be involved in physiological and pathological mechanisms of their oral cavity. The present study aimed to characterize the proteomic profile of saliva from dogs with and without dental calculus.

Results: Saliva samples were collected from 20 dogs. Before the collection, a visual clinical examination was performed and 8 subjects (40%) did not present any signs of dental calculus, while 12 (60%) presented dental calculus. After saliva collection, the samples were submitted to protein quantification (mBCA), and then they were prepared for analysis by nLC-ESI-MS/MS. A total of 658 unique proteins were identified, of which 225 were specific to dogs without dental calculus, 300 were specific to dogs with dental calculus, and 133 were common to all subjects. These proteins presented functions including transportation, immune response, structural, enzymatic regulation, signal transduction, transcription, metabolism, and some proteins perform functions as yet unknown. Several salivary proteins in dogs with dental calculus differed from those found in the group without dental calculus. Among the abundant proteins detected in periodontal affected cases, can be highlighting calcium-sensing receptor and transforming growth factor beta. Enrichment analysis reveled the presence of Rho GTPases signaling pathway.

Conclusions: This research identified salivary proteins, that should be further investigated as potencial biomarkers of chronic periodontits with dental calculus formation in dogs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437026PMC
http://dx.doi.org/10.1186/s12917-020-02514-0DOI Listing

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