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Current perspectives on the rehabilitation of COPD patients with comorbidities.
Expert Rev Respir Med
January 2025
Cardiorespiratory Rehabilitation Laboratory, University of Santa Cruz do Sul, Rio Grande do Sul, Brazil.
Introduction: Chronic obstructive pulmonary disease (COPD) is frequently accompanied by a variety of comorbidities, complicating management and rehabilitation efforts. Understanding this interplay is crucial for optimizing patient outcomes.
Areas Covered: This review, based on the MEDLINE, Embase and Cochrane Library databases, summarizes the main research on the rehabilitation of patients with COPD, with an emphasis on relevant comorbidities, such as cardiovascular diseases, pulmonary hypertension, lung cancer, metabolic, musculoskeletal, and gastrointestinal disorders.
The Influence of Electroencephalographic Density Spectral Array Guidance of Sevoflurane Administration on Recovery From General Anesthesia in Children. A Randomized Controlled Trial.
Paediatr Anaesth
January 2025
Department of Anesthesia, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Background: In children, monitoring depth of anesthesia is challenging because of the still developing brain. Electroencephalographic density spectral array monitoring provides age- and anesthetic drug-specific electroencephalographic patterns, making it suitable for use in children. Yet, not much is known about the benefits of using density spectral array on post-operative recovery in children.
View Article and Find Full Text PDFDeterminants of Prolonged Hospitalization in Children and Adolescents: A Retrospective Observational Study.
J Nurs Scholarsh
January 2025
Section of Hygiene, University Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.
Introduction: Ensuring an appropriate length of stay (LOS) is a primary goal for hospitals, as prolonged LOS poses clinical risks and organizational challenges. Children and adolescents are particularly susceptible to prolonged LOS due to frequent hospitalizations and unique vulnerabilities, including developmental disabilities that may necessitate additional care and monitoring. This study aims to describe the LOS of children and adolescent patients and identify the sociodemographic, organizational, clinical, and nursing care factors contributing to prolonged LOS in this population.
View Article and Find Full Text PDFRapid microfluidic perfusion system enables controlling dynamics of intracellular pH regulated by Na/H exchanger NHE1.
Lab Chip
January 2025
CNRS UMR 7010, Institut de Physique de Nice (INPHYNI), Université Côte d'Azur, 06108 Nice, France.
pH regulation of eukaryotic cells is of crucial importance and influences different mechanisms including chemical kinetics, buffer effects, metabolic activity, membrane transport and cell shape parameters. In this study, we develop a microfluidic system to rapidly and precisely control a continuous flow of ionic chemical species to acutely challenge the intracellular pH regulation mechanisms and confront predictive models. We monitor the intracellular pH dynamics in real-time using pH-sensitive fluorescence imaging and establish a robust mathematical tool to translate the fluorescence signals to pH values.
View Article and Find Full Text PDFEnhanced detection of Brain-Derived Neurotrophic Factor (BDNF) using a reduced graphene oxide field-effect transistor aptasensor.
Nanoscale
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health and economic challenges. Brain-Derived Neurotrophic Factor (BDNF), a key regulator of neuroplasticity and neuronal survival, has emerged as a critical biomarker for various neurodegenerative and psychiatric disorders, including Alzheimer's disease. Traditional diagnostic methods, such as Enzyme-Linked Immunosorbent Assay (ELISA) and electrochemiluminescence (ECL) assays, face limitations in terms of sensitivity, stability, reproducibility, and cost-effectiveness.
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