AI Article Synopsis
- The study investigates how the FTO obesity-risk allele (SNP rs9939609) affects energy and substrate expenditure in individuals who are uniformly obese.
- Participants included 100 individuals categorized based on their FTO allele status: non-risk homozygotes (TT), heterozygotes (AT), and risk homozygotes (AA).
- Findings show no significant differences in basal metabolic or post-meal energy expenditure across groups, but those with the risk allele had a higher fasting respiratory quotient, indicating changes in fat and carbohydrate oxidation.
Article Abstract
Purpose: The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity . Against this background, we investigated the impact of FTO allele (SNP rs9939609) on fasting and postprandial energy expenditure and fasting substrate expenditure in a study population of uniformly and similarly obese individuals.
Procedures: We studied a similar number of participants with BMI classes 2-3 (median BMI 42.8 kg/m) who were either homozygote for the non-risk allele TT (n = 33, numbers increased by enrichment), heterozygote (AT) (n = 32), or homozygote for the risk allele AA (n = 35).
Major Findings: Basal metabolic rate and postprandial energy expenditure did not differ between FTO-groups. However, fasting respiratory quotient (RQ) was increased in those carrying ≥1 risk allele (p = 0.008), whereas postprandial RQ was not.
Conclusion: In this study population, the FTO-risk allele associates with fasting reduced fat and increased carbohydrate oxidation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424829 | PMC |
| http://dx.doi.org/10.1016/j.metop.2019.02.001 | DOI Listing |
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