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Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia.
BMJ Open Diabetes Res Care
December 2024
Department of Medicine, The University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee, USA
Introduction: Ethnic disparities in the prevalence and pathophysiology of type 2 diabetes are well documented, but prospective data on insulin dynamics vis-à-vis pre-diabetes/early dysglycemia risk in diverse populations are scant.
Research Design And Methods: We analyzed insulin secretion, sensitivity, and clearance among participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study. The POP-ABC study followed initially normoglycemic offspring of parents with type 2 diabetes for 5.
Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie diet.
Clin Obes
December 2024
Human Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
The endocrine consequences of weight loss by bariatric surgery (BS) and caloric restriction are not fully understood but contribute to variable improvements in insulin sensitivity and cardiometabolic health. This study compared changes in insulin sensitivity and plasma concentrations of gut peptides 8 weeks and 1 year after BS and a low-calorie diet (LCD). Nineteen female patients with obesity self-selected BS (gastric bypass [n = 5] or sleeve gastrectomy [n = 7]) or LCD (n = 7) in this parallel-arm, prospective observational study.
View Article and Find Full Text PDFThe Role of Dapagliflozin in the Modulation of Hypothermia and Renal Injury Caused by Septic Shock in Euglycemic and Hyperglycemic Rat Models.
Curr Mol Pharmacol
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Background: Recent research has validated the efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in reducing glucose levels and exerting a nephroprotective role.
Objective: This study aimed to examine the impact of dapagliflozin in preventing sepsis-induced acute kidney injury (AKI) and related consequences. The study used both normal and diabetic rat models to investigate whether the effectiveness of dapagliflozin is influenced by glycemia levels.
Gestational diabetes mellitus and linear growth in early childhood.
Front Endocrinol (Lausanne)
December 2024
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Introduction: Gestational diabetes mellitus (GDM) is a common pregnancy complication with potential short- and long-term adverse consequences for both mothers and fetuses. It is unclear whether GDM affects linear growth in the offspring; research data are limited and inconsistent.
Methods: In a prospective birth cohort in Shanghai (n=2055 children; 369 born to mothers with GDM).
Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism.
Cardiovasc Diabetol
December 2024
Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.
Background: Increased whole blood viscosity (WBV) was associated with impaired peripheral glucose metabolism, type 2 diabetes, and cardiovascular disease (CVD). Impaired myocardial glucose metabolism is a risk factor for CVD. Whether an increased WBV is associated with impaired myocardial glucose metabolism is still undefined.
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