This study was conducted to develop biodegradable cellulose scaffolds by oxidising porous cellulose sponges for tissue engineering applications. Cellulose powder was dissolved in ionic liquid using a salt leaching method, and porous cellulose scaffolds of various pore sizes were prepared. The scaffolds were oxidised with periodate to introduce aldehyde at a rate controlled by the periodate concentration. Oxidised scaffolds exhibited weight loss in cell culture medium, but not in phosphate buffer. Therefore, we confirmed that Schiff base formation between the aldehyde and amino groups through a Maillard reaction triggered cellulose molecular degradation. The degradation rate was controlled by the oxidation degree, whereas the aldehyde content controlled protein adsorption and cell proliferation. Additionally, in vivo implantation tests revealed that optimising the oxidation ratio not only improved biodegradability but also reduced inflammation. In conclusion, our results suggest that simple oxidised cellulose is useful as a low-toxicity biodegradable scaffold.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d0tb01015d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cellulose Based Nano-Scaffolds for Targeted Cancer Therapies: Current Status and Future Perspective.
Int J Nanomedicine
January 2025
Department of General Practice and Family Medicine, The Second Hospital of Jilin University, Changchun, 130000, People's Republic of China.
In the last few years, cellulose has garnered much interest for its application in drug delivery, especially in cancer therapy. It has special properties like biocompatibility, biodegradability, high porosity, and water permeability render it a good candidate for developing efficient carriers for anticancer agents. Cellulose based nanomaterials like cellulose nanofibers, bacterial cellulose, cellulose nanocrystals and microcrystalline cellulose as delivery vehicles for targeted drug delivery to cancer cells are reviewed.
View Article and Find Full Text PDFRadiation-assisted tailoring of swelling behavior and water retention of Na-CMC/PAAm hydrogels for enhancing Beta Vulgaris under drought stress.
Sci Rep
January 2025
Radiation Research of Polymer Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
This study investigates the negative impact of climate change on water resources, specifically water for agricultural irrigation. It describes how to optimize swelling, gel properties and long-term water retention capacities of Na-CMC/PAAm hydrogels for managing drought stress of Sugar beet plants through techniques such as changing the composition, synthetic conditions and chemical modification. Gamma radiation-induced free radical copolymerization was used to synthesize superabsorbent hydrogels using sodium carboxymethyl cellulose (Na-CMC) and acrylamide (AAm).
View Article and Find Full Text PDFDesign of boron nitride/nanocellulose aerogel-stabilized phase change materials for efficient thermal energy capture and storage.
Int J Biol Macromol
January 2025
Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B5A3, Canada.
The practical application of polyethylene glycol (PEG) phase change materials (PCMs) necessitates exceptional shape stability, rapid thermal responsiveness, and a substantial thermal storage capacity. The present study focuses on the fabrication of a highly robust cellulose nanofibril (CNF) based aerogel with an ordered structure, serving as a three-dimensional (3D) scaffold for PEG to effectively prevent any potential leakage. Additionally, hydroxyl and amino functional groups are introduced to functionalize boron nitride nanosheets (BNNS-g), which are incorporated into the aerogel to enhance its thermal conductivity.
View Article and Find Full Text PDFHighly Flexible Methyl Cellulose/Gelatin Hydrogels for Potential Cartilage Tissue Engineering Applications.
Biopolymers
January 2025
Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey.
Cartilage damage resulting from trauma demonstrates a poor capacity for repair due to its avascular nature. Cartilage tissue engineering offers a unique therapeutic option for cartilage recovery. In this study, methylcellulose (MC)/gelatin (GEL) hydrogels (MC10G20, MC12.
View Article and Find Full Text PDFInvestigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering.
Int J Mol Sci
December 2024
Institute of Technical Physics and Materials Science, HUN-REN Centre for Energy Research, Konkoly-Thege str. 29-33, H-1121 Budapest, Hungary.
We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were synthesized via wet chemical precipitation, followed by the addition of organic biominerals, such as magnesium gluconate and zinc gluconate, to enhance the bioactivity of the pure CP phase.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!