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Visible-Light-Absorbing Photosensitizer Nanostructures for Treatment of Pathogenic Bacteria and Induction of Systemic Acquired Resistance.
ACS Nano
December 2024
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Induction of systemic acquired resistance (SAR) in plants to control bacterial diseases has become an effective solution to the problems of agrochemical resistance and ecological environment damage caused by long-term and large-scale use of traditional bactericides. However, current SAR-inducing compounds are often unable to rapidly eliminate pathogenic bacteria in infected plant tissues to prevent further spread of the disease, severely restraining the potential for extensive application in agriculture. Herein, we address the limitations by developing a series of visible-light-absorbing aggregation-induced emission photosensitizers suitable for agricultural use.
View Article and Find Full Text PDFRoles and Mechanisms of Ferroptosis in Sorafenib Resistance for Hepatocellular Carcinoma.
J Hepatocell Carcinoma
December 2024
Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, 541199, People's Republic of China.
Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, characterized by a poor prognosis. In recent decades, both the incidence and mortality rates of HCC have risen sharply. Sorafenib has emerged as the first conventional drug approved by the US Food and Drug Administration for first-line treatment in advanced HCC patients due to its favorable safety profile.
View Article and Find Full Text PDFA Three-Year Analysis of Mortality in Clostridioides difficile Patients in a Tertiary Center.
Cureus
November 2024
Infectious Diseases, Clinic Hospital of Tropical and Infection Diseases "Dr. Victor Babes", Bucharest, ROU.
Background/objectives: , an anaerobic bacillus ubiquitous in nature, is the leading cause of hospital-acquired diarrhoea and one of the main causes of mortality by nosocomial infections. We aimed to identify the main predictors of the risk of dying and the characteristics of a three-year cohort of patients hospitalised in our clinic that eventually had an unfavourable outcome.
Methods: We collected retrospectively available data for all patients hospitalised between January 1, 2021, and December 31, 2023.
Enhancing cancer radiotherapy efficacy using NanOx, a novel oxygenating perfluorocarbon nanoemulsion that reverses tumour hypoxia.
Cancer Lett
December 2024
Trinity St James Cancer Institute, Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin.
Radiotherapy is used to treat over 50% of cancer patients. It is often used in combination with surgery, chemotherapy, and immunotherapy, for cancers of the breast, lung, oesophagus, and rectum. Ionising radiation predominantly exerts its anti-cancer effect through both direct DNA damage and indirectly via water radiolysis and the production of reactive oxygen species.
View Article and Find Full Text PDFIndividualized identification value of stress-related network structural-functional properties and HPA axis reactivity for subthreshold depression.
Transl Psychiatry
December 2024
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Accumulating studies have highlighted the links between stress-related networks and the HPA axis for emotion regulation and proved the mapping associations between altered structural and functional networks (called SC-FC coupling) in depression. However, the signatures of SC-FC coupling in subthreshold depression (StD) individuals and their relationships with HPA axis reactivity, as well as the predictive power of these combinations for discriminating StD, remain unclear. This cross-sectional study enrolled 160 adults, including 117 StD and 43 healthy controls (HC).
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