AI Article Synopsis
- FABP7 is a fatty acid chaperone found in certain brain cells and plays a role in how these cells respond to external signals by regulating caveolin-1 expression.
- The study used astrocytes lacking FABP7 and NIH-3T3 cells with increased FABP7 to examine its effects on caveolin-1.
- The researchers found that FABP7 interacts with ATP-citrate lyase (ACLY) in the nucleus, affecting acetyl-CoA metabolism, which in turn influences gene regulation, particularly through changes in histone acetylation that impact cell functions related to caveolae.
Article Abstract
Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular stimuli by controlling the expression of caveolin-1, an important component of lipid raft. Here, we explored the detailed mechanisms underlying FABP7 regulation of caveolin-1 expression using primary cultured FABP7-KO astrocytes as a model of loss of function and NIH-3T3 cells as a model of gain of function. We discovered that FABP7 interacts with ATP-citrate lyase (ACLY) and is important for acetyl-CoA metabolism in the nucleus. This interaction leads to epigenetic regulation of several genes, including caveolin-1. Our novel findings suggest that FABP7-ACLY modulation of nuclear acetyl-CoA has more influence on histone acetylation than cytoplasmic acetyl-CoA. The changes to histone structure may modify caveolae-related cell activity in astrocytes and tumors, including malignant glioma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541391 | PMC |
| http://dx.doi.org/10.1007/s12035-020-02057-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!