Identification and characterization of spp. and their susceptibility to insect apolipophorin III.

This study investigated the effect of an insect antimicrobial protein, apolipophorin III (apoLp-III), against two newly isolated, identified and characterized clinical strains of spp. Both strains were identified by 16S rRNA sequencing and metabolic and phenotypic profiling. The antibacterial activity of apoLp-III was tested using a colony counting assay. ApoLp-III interaction with bacterial cell surface was analyzed by Fourier transform IR spectroscopy. and were identified. ApoLp-III exerted a dose-dependent bactericidal effect on the tested strains. The differences in the spp. surface components may contribute to the various sensitivities of these strains to apoLp-III. ApoLp-III may provide a baseline for development of antibacterial preparations against spp. involved in dermatological problems.