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Comparison of the Modified CTOD Measurement Method with the Double Clip Gauge Method in a Compact Tension Specimen.
Materials (Basel)
January 2025
Smart Forming Process Group, Korea Institute of Industrial Technology, Ulsan 44776, Republic of Korea.
For allowable defect analyses, the fracture toughness of materials needs to be accurately predicted. In this regard, a lower fluctuation of fracture toughness can lead to reduction in safety and economic risks. Crack tip opening displacement (CTOD), which is the representative parameter for fracture toughness, can be measured by various methods, such as the δ5, the J-conversion method, the single clip gauge method, and the double clip gauge method.
View Article and Find Full Text PDFIntegrating New Approach Methodologies to Address Environmental Pancreatic Toxicity and Metabolic Disorders.
Biology (Basel)
January 2025
Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Advancing our understanding of pancreatic toxicity and metabolic disorders caused by environmental exposures requires innovative approaches. The pancreas, a vital organ for glucose regulation, is increasingly recognized as a target of harm from environmental chemicals and dietary factors. Traditional toxicological methods, while foundational, often fail to address the mechanistic complexities of pancreatic dysfunction, particularly under real-world conditions involving multiple exposures.
View Article and Find Full Text PDFWhat enabled the successful implementation of a quality certification initiative in Bhavnagar, Gujarat? A policy analysis case study.
PLOS Glob Public Health
January 2025
Indian Institute of Public Health, Gandhinagar, Gujarat, India.
High-quality health systems are key to improving population health outcomes globally. In India, the National Quality Assurance Standards (NQAS) is a certification policy adopted by the government to improve the quality of care in public health facilities. This policy aims to assess public health facilities through a set of comprehensive, pre-defined standards derived from global best practices.
View Article and Find Full Text PDFValidation of Härtel Surface Anatomical Landmarks for Locating the Foramen Ovale: A Computed Tomography Scan Analysis and Revised Technique Description.
Oper Neurosurg (Hagerstown)
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Neurosurgical Department, Hospital Italiano de Buenos Aires, CABA, Buenos Aires, Argentina.
Background And Objectives: Härtel triangle provides surface landmarks for locating the foramen ovale (FO) when performing trigeminal nerve percutaneous procedures. Although widely adopted in clinical practice, there is no report that these landmarks have ever been formally validated through modern imaging techniques. Here we aim to validate Härtel anatomical landmarks using computed tomography scans and propose technical considerations for percutaneous trigeminal procedures.
View Article and Find Full Text PDFConsensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity.
Environ Mol Mutagen
January 2025
Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.
Article Synopsis
- Gene expression biomarkers can help identify both genotoxic and non-genotoxic carcinogens, which could reduce the need for animal testing.
- In August 2022, a workshop reviewed current methods for using transcriptomic profiling to detect genotoxic chemicals, examining 1341 papers to find reliable biomarkers.
- The analysis identified two promising in vivo biomarkers and three in vitro biomarkers that show over 92% predictive accuracy and can be adapted for various testing conditions, with support from workshop participants for their regulatory adoption.
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