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Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn's disease. | LitMetric

Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn's disease.

Nat Commun

Shanghai Institute of Materia Medica-University of Ottawa Joint Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.

Published: August 2020

AI Article Synopsis

Article Abstract

Lysine acetylation (Kac), an abundant post-translational modification (PTM) in prokaryotes, regulates various microbial metabolic pathways. However, no studies have examined protein Kac at the microbiome level, and it remains unknown whether Kac level is altered in patient microbiomes. Herein, we use a peptide immuno-affinity enrichment strategy coupled with mass spectrometry to characterize protein Kac in the microbiome, which successfully identifies 35,200 Kac peptides from microbial or human proteins in gut microbiome samples. We demonstrate that Kac is widely distributed in gut microbial metabolic pathways, including anaerobic fermentation to generate short-chain fatty acids. Applying to the analyses of microbiomes of patients with Crohn's disease identifies 52 host and 136 microbial protein Kac sites that are differentially abundant in disease versus controls. This microbiome-wide acetylomic approach aids in advancing functional microbiome research.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431864PMC
http://dx.doi.org/10.1038/s41467-020-17916-9DOI Listing

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