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Combining Ionic Groups with Methallyl Dichloride Coupling delivers New Pathways to Ionic/Non-ionic Hybrid Detergents.
Chempluschem
January 2025
TU Dortmund: Technische Universitat Dortmund, Chemistry and Chemical Biology, Otto-Hahn-Str. 6, 44227, Dortmund, GERMANY.
Strategies for combining ionic and non-ionic functional groups are important for altering detergent properties and exploring new chemical spaces within the detergentome. Previous synthesis protocols for ionic/non-ionic hybrid detergents require asymmetric detergent precursors with independently addressable hydroxyl groups that can be decorated with charged groups. However, preparation of ionic/non-ionic headgroups can be tedious in terms of required synthesis steps and resource consumption.
View Article and Find Full Text PDFPreparation of oat galactolipid and anti-liver cancer effects of oat galactolipid-modified curcumin-loaded liver targeting vesicle.
Front Pharmacol
January 2025
Hubei Shizhen Laboratory, Wuhan, China.
Introduction: The mortality rate for liver cancer is extremely high but clinical treatments have not made much progress, so it is necessary to develop anticancer agents with lower toxicities and more effective liver-targeting drug delivery systems (LTDDSs). At present, LTDDSs mediated by the asialoglycoprotein receptor (ASGPR) show excellent effects at improving the liver-targeting and antitumor effects of drugs. However, the galactosyl ligands are typically prepared by chemical synthesis and have some shortcomings.
View Article and Find Full Text PDFFluorometric Turn Off Detection of Cu and Pd Ions Using 1-(Imidazo[5,1-a]isoquinolin-3-yl)naphthalen-2-ol.
Luminescence
January 2025
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
The fused heterocycle 1-(imidazo[5,1-a]isoquinolin-3-yl)naphthalen-2-ol (LH) has been synthesized and characterized by spectroscopic methods. Probe LH upon irradiation with λ = 336 nm exhibited strong fluorescence with λ = 437 nm in MeOH/HEPES buffer (5 mM, pH = 7.4, 2:8, v/v).
View Article and Find Full Text PDFDual-Asymmetric Solid Additive Enables Eco-friendly All-Polymer Solar Cells with Over 19% Efficiency and Excellent Stability.
Angew Chem Int Ed Engl
January 2025
Guangzhou University, Center for Advanced Analytical Science, c/o School of Chemistry and Chemical Engineering, 230 Wai Huan Xi Road, Guangzhou Higher Education Mega Center, Guangzhou 510006 P, 510006, Guangzhou, CHINA.
The optimization of morphology in all-polymer solar cells (all-PSCs) often relies on the use of solvent additives. However, their tendency to remain trapped in the device due to high boiling points leads to performance degradation over time. In this study, we introduce a novel approach involving the design and synthesis of one dual-asymmetric solid additive featuring mono-brominated-asymmetric dithienothiophene (SL-1).
View Article and Find Full Text PDFStructure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers.
J Med Chem
January 2025
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Simultaneous inhibition of the bromodomain and extra-terminal domain and Aurora kinases is a promising anticancer therapeutic strategy. Based on our previous study on BET-kinase dual inhibitors, we employed the molecular docking approach to design novel dual BET-Aurora kinase A inhibitors. Through several rounds of optimization and with the guidance of the solved cocrystal structure of BRD4 bound to inhibitor , we finally obtained a series of highly potent dual BET-Aurora kinase A inhibitors.
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