Staging procedures fail to benefit women with borderline ovarian tumours who want to preserve fertility: a retrospective analysis of 448 cases.

BMC Cancer

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.

Published: August 2020

Background: To evaluate the effect of clinicopathologic factors on the prognosis and fertility outcomes of BOT patients.

Methods: We performed a retrospective analysis of BOT patients who underwent surgical procedures in West China Second University Hospital from 2008 to 2015. The DFS outcomes, potential prognostic factors and fertility outcomes were evaluated.

Results: Four hundred forty-eight patients were included; 52 recurrences were observed. Ninety-two patients undergoing FSS achieved pregnancy. No significant differences in fertility outcomes were found between the staging and unstaged surgery groups. Staging surgery was not an independent prognostic factor for DFS. Laparoscopy resulted in better prognosis than laparotomy in patients with stage I tumours and a desire for fertility preservation.

Conclusion: Patients with BOT fail to benefit from surgical staging. Laparoscopy is recommended for patients with stage I disease who desire to preserve fertility. Physicians should pay more attention to risk of recurrence in patients who want to preserve fertility.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433083PMC
http://dx.doi.org/10.1186/s12885-020-07262-wDOI Listing

Publication Analysis

Top Keywords

preserve fertility
12
fertility outcomes
12
fail benefit
8
retrospective analysis
8
patients stage
8
fertility
7
patients
7
staging
4
staging procedures
4
procedures fail
4

Similar Publications

[Clinical characteristics and prognosis of ovarian juvenile granulosa cell tumors].

Zhonghua Fu Chan Ke Za Zhi

January 2025

Department of Gynecology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing100021, China.

To analyze the clinical characteristics, treatments, and prognosis of patients with ovarian juvenile granulosa cell tumor (JGCT). Clinical and pathological data, and follow-up information of 34 patients diagnosed with JGCT from 2000 to 2021 were collected from the surveillance, epidemiology, and end results (SEER) database. A retrospective analysis was conducted to summarize the patients' clinical and pathological characteristics, treatments, and prognosis.

View Article and Find Full Text PDF

Context: The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction. Although ginsenoside Rg1 is known to modulate mitophagy, its effectiveness in mitigating ovarian reserve decline remains unclear.

Objective: To investigate the role of ginsenoside Rg1 in promoting mitophagy to preserve ovarian reserve.

View Article and Find Full Text PDF

Repeated expeditions across various regions of Georgia in the early 2000s led to the identification of 434 wild grapevine individuals ( L. subsp. (C.

View Article and Find Full Text PDF

Phosphorus (P) availability in soils is often constrained by its accumulation in non-labile phosphorus (NLP) forms, limiting its accessibility to plants. This study examines how soil physical properties, chemical characteristics, and climatic conditions influence phosphorus fractionation and the transformation of NLP into plant-available labile phosphorus (LP). Utilizing global structural equation modeling (SEM), we found that silt content enhances organic phosphorus fractions, including NaHCO-Po and NaOH-Po.

View Article and Find Full Text PDF

: The use of antibiotics in livestock contributes to antimicrobial resistance, highlighting the need for alternative solutions. Among these, chelating agents, like ethylenediaminetetraacetic acid (EDTA) and Chitosan, have shown potential in reducing bacterial contamination in seminal doses used in artificial insemination (AI), while preserving sperm quality. The objective of this study was to evaluate the potential use of EDTA and Chitosan as alternatives to antibiotics for the liquid storage of rabbit seminal AI doses.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!