is a newly described animal pathogen, closely related to the emerging human pathogen and , a major pathogen of small ruminants. In this study, proteins of a whole cell and a shaving fraction and the exoproteome of strain W25 were analyzed as a first proteome study of this species. In total, 1305 proteins were identified out of 2013 proteins encoded by the W25 genome sequence and number of putative virulence factors were detected already under standard growth conditions including phospholipase D and sialidase. An up to now uncharacterized trypsin-like protease is by far the most secreted protein in this species, indicating a putative role in pathogenicity. Furthermore, the proteome analyses carried out in this study support the recently published taxonomical delineation of from the closely related zoonotic species.
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| http://dx.doi.org/10.3390/proteomes8030019 | DOI Listing |
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