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Copper-catalyzed dearomatization and difunctionalization of pyridines have been disclosed, in which bromodifluoro--arylacetamide was sliced into five fragments and three or four of them were transferred to pyridine partners. Through this reaction, novel -difluoromethyl-2-imine dihydropyridine derivatives can be conveniently accessed from commercially available 4-amino substituted pyridines. This strategy demonstrates a novel fluorination method featuring high atom economy, environmental friendliness, an easily available catalyst, and simple operation.
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