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Photocatalytic Intramolecular C-H Amination Using -Oxyureas as Nitrene Precursors. | LitMetric

Photocatalytic Intramolecular C-H Amination Using -Oxyureas as Nitrene Precursors.

Org Lett

Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

Published: August 2020

Nitrenes are remarkable high-energy chemical species that enable direct C-N bond formation, typically via controlled reactions of metal-stabilized nitrenes. Here, in contrast, the combined use of photocatalysis with careful engineering of the precursor enabled C-H amination forming imidazolidinones and related nitrogen heterocycles from readily accessible hydroxylamine precursors. Preliminary mechanistic results are consistent with the formation of free carbamoyl triplet nitrenes as reactive intermediates.

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Source
http://dx.doi.org/10.1021/acs.orglett.0c02200DOI Listing

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