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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478387 | PMC |
http://dx.doi.org/10.1097/CM9.0000000000001048 | DOI Listing |
Diagnostics (Basel)
February 2025
Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
This report discusses a female patient with longstanding discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), refractory to multiple immunosuppressive and biologic treatments. Upon presenting with infiltrated, hypertrophic plaques in facial and décolletage regions, she was started on anifrolumab therapy after the histopathological confirmation of DLE. Following three infusions, significant clinical and dermoscopic improvements were observed, including the resolution of plaques and regression of scarring areas.
View Article and Find Full Text PDFCancers (Basel)
February 2025
Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 53100 Siena, Italy.
Basal cell carcinoma (BCC) is the most common malignancy, characterised by local invasiveness and the potential for tissue destruction. Diagnosing BCC can be challenging, particularly for less experienced dermatologists. Line-field confocal optical coherence tomography (LC-OCT), a new noninvasive optical technique, has become increasingly useful in clinical practice, allowing in vivo imaging at cellular resolution.
View Article and Find Full Text PDFCancers (Basel)
February 2025
Dermatology Resident Training Program, Department of Medicine and Surgery, University of Parma, 43121 Parma, Italy.
Background/objectives: The prevalence of tattoos has risen globally in recent decades, ranging from 10% to 29%. Although rare, melanomas arising within tattoos are challenging for dermatologists due to the complexities in clinical and dermoscopic evaluation. In this article, we report two cases of melanoma on tattoos, review the reported cases in the literature, and examine the role of reflectance confocal microscopy (RCM) in improving the diagnosis of melanoma on tattooed skin.
View Article and Find Full Text PDFJ Cutan Med Surg
March 2025
Department of Dermatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
Background: Early melanomas, dysplastic melanocytic nevi, and melanocytic tumours of uncertain malignant potential (MELTUMPs) reveal similar clinic and dermoscopic findings leading to underdiagnosis of malign lesions or unnecessary excision of benign ones. High-grade dysplastic nevi and MELTUMPs in the intermediate category should be recognized and completely excised.
Objectives: We evaluated the diagnostic performance of pattern analysis, ABCD rule, colour, architecture, symmetry, and homogeneity algorithm, melanoma-specific structures and asymmetry of dermoscopic features in distinguishing early melanomas, high-grade dysplastic nevi, and MELTUMPs from low-grade dysplastic nevi.
Background: Androgenic alopecia (AGA) is a widespread form of hair loss characterized by the gradual reduction in follicular size and reduced hair density, with unsatisfactory treatments.
Aims: This study explores the therapeutic potential of a novel fermented extract, Thermus thermophilus fermentation extract (TTFE), in mitigating the effects of AGA.
Methods: The research integrates in vitro assays utilizing various hair-growth-related cells with a 12-week clinical trial involving 32 male subjects diagnosed with AGA.
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