AI Article Synopsis
- Lipids in cell membranes may affect Alzheimer's disease by influencing certain enzyme activities.
- Researchers assessed plasma lipid profiles in individuals with mild cognitive impairment (MCI), distinguishing between those with and without Alzheimer’s pathology.
- The study found lower levels of a specific sphingomyelin lipid in MCI participants with Alzheimer's pathology compared to controls, but no significant links to neuropsychological test performance were identified.
Article Abstract
Background: Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence β- and γ-secretase activities and thus contribute to Alzheimer's disease (AD) pathology.
Objective: To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology.
Methods: We identified 261 plasma lipids using reversed-phase liquid chromatography/mass spectrometry in cerebrospinal fluid amyloid positive (Aβ+) or negative (Aβ-) participants with MCI as compared to controls. Additionally, we analyzed the potential associations of plasma lipid profiles with performance on neuropsychological tests at baseline and after two years.
Results: Sphingomyelin (SM) concentrations, particularly, SM(d43:2), were lower in MCI Aβ+ individuals compared to controls. Further, SM(d43:2) was also nominally reduced in MCI Aβ+ individuals compared to MCI Aβ-. No plasma lipids were associated with performance on primary neuropsychological tests at baseline or between the two time points after correction for multiple testing.
Conclusion: Reduced plasma concentrations of SM were associated with AD.
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| http://dx.doi.org/10.3233/JAD-200441 | DOI Listing |
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