An Improved Synthesis of the Triethylene Glycol-Substituted 4-(-Methyl--Boc-Amino)Styrylpyridine.

An improved five-step synthesis of triethylene glycol-substituted 4-(-methyl--Boc-amino)styrylpyridine () is described. Using cost-effective starting materials, the developed synthesis route was synthetic, efficient, and chromatographic purification-free. The key point of the work is the one-pot synthesis of -butyl methyl(4-vinylphenyl)carbamate through methylation and elimination in the NaH/THF system. The new synthesis route shows the potential to achieve scaled-up preparation of in the future.