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| http://dx.doi.org/10.1097/GOX.0000000000003022 | DOI Listing |
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Impact of Prepectoral Implant Placement and Radiation Modalities (Protons/Photons/Dosimetry) in Mastectomy Patients Undergoing Immediate Single Stage Direct-to-Implant Breast Reconstruction.
Int J Radiat Oncol Biol Phys
November 2024
Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
Article Synopsis
- The study examines complications related to immediate breast reconstruction after mastectomy in patients with and without postmastectomy radiotherapy (PMRT), comparing pre-pectoral and subpectoral implant placements.
- Out of 3,039 patients reviewed between 2005 and 2020, 815 met the criteria for analysis, with a follow-up of 6.2 years, showing no significant differences in major complications between the two implant placements.
- The results indicated that while there was no notable difference in infection or reconstruction failures between proton and photon therapies, patients undergoing proton therapy had a higher risk of capsular contracture and overall reconstruction failure.
Case report: Efficacy of later-line fam-trastuzumab deruxtecan in a patient with triple-positive breast cancer with brain metastases.
Front Oncol
November 2024
Department of Oncology, Centro Hospitalar Conde de São Januário, Macao, Macao SAR, China.
Fam-trastuzumab deruxtecan (T-DXd) has demonstrated substantial antitumor activity and durable responses in patients with human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer. We report here the treatment outcomes of T-DXd in a patient with HER2+ breast cancer with brain metastases that repeatedly recurred and progressed after two lines of salvage therapy. In 2016, a 23-year-old G0P0 female with risk factors including menarche at age 9 years, Li-Fraumeni syndrome, and a strong family history of cancer was diagnosed with bilateral, triple-positive breast cancer.
View Article and Find Full Text PDFOncological and Surgical Outcomes of Oncoplastic Reduction Mammoplasty: A Single-centre Retrospective Study.
In Vivo
October 2024
Department of Plastic, Reconstructive, and Aesthetic Surgery, Geneva University Hospitals, Geneva University, Geneva, Switzerland;
Background/aim: Breast-conserving surgery is the preferred treatment for early-stage breast cancer but can often result in unsatisfactory cosmetic outcomes. Oncoplastic surgery aims to improve both oncologic and aesthetic outcomes by combining local excision with plastic surgery techniques. Using breast reduction techniques in breast cancer treatment has been shown to allow for wider margins of excision, leading to enhanced oncological safety and reduced recurrence rates without causing significant asymmetry.
View Article and Find Full Text PDFManagement of the Infected Tissue Expander.
Plast Reconstr Surg
October 2024
Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Background: Tissue expander (TE) infection is a critical postoperative complication in two-stage implant-based breast reconstruction (IBBR). We assessed risk factors associated with TE infection and reconstructive loss and examined reconstructive salvage rates.
Methods: We retrospectively reviewed patients who underwent IBBR with TE placement from 2017 to 2022.
Metaplastic breast cancer: Experience with ifosfamide based chemotherapy.
Curr Probl Cancer
December 2024
Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
Background: Metaplastic breast cancer (MPBC) is a rare variant of breast cancer and most treatment protocols are based on the guidelines for triple negative breast cancer. However, response to standard anthracycline and taxane based chemotherapy is poor. Published literature on use of ifosfamide based chemotherapy in the first line setting for MPBC is scarce.
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