Effectiveness of including probiotics to eradication therapies.

The eradication rate of () with proton pump inhibitors, amoxicillin, and clarithromycin has reportedly decreased. Some studies have found probiotics to be useful in eradicating , but these effects have not been sufficiently investigated. We aimed to elucidate the role of probiotics in eradicating infection. Patients in our hospital with infection that received standard treatment from January 2015 to December 2016 were retrospectively evaluated ( = 468). They were divided into three groups based on their treatment regime, being either proton pump inhibitors, amoxicillin, or clarithromycin (PPI group), vonoprazan, amoxicillin, or clarithromycin (VPZ group), and proton pump inhibitors, amoxicillin, or clarithromycin/probiotics (Miya-BM) (PPI + MBM group). We retrospectively evaluated the eradication rate and reported side effects. According to intention-to-treat analyses, the eradication rate of was significantly higher in the PPI + MBM group (87.1%) than in the PPI group (70.1%). There was no difference in side effects between any of the three groups. In conclusion, Miya-BM may have an additive effect when included with eradication therapies for .