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Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran.
Asian J Transfus Sci
December 2022
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Background: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization.
View Article and Find Full Text PDFABO isoagglutinin titers in group "O" blood donors.
Asian J Transfus Sci
October 2024
Department of Transfusion Medicine, Sri Balaji Action Medical Institute, New Delhi, India.
Background: High titers of anti-A and anti-B are considered to be one reason for hemolytic transfusion reactions and ABO hemolytic disease in fetus and neonates. There is no consensus for critical ABO antibody titers to guide transfusion or transplant decisions. Implementation of ABO titer measurement can favor reduction in transfusion reactions in nongroup "O" recipients.
View Article and Find Full Text PDFIntroduction: Organ donation refers to the collection of a human organ from a living or deceased donor and its transplantation into a recipient. An organ transplant recipient is a patient with organ failure who will not survive unless he receives a new organ. Although the benefits of organ transplantation are undeniable, there is a significant gap between the number of donors and recipients, as the demand for organs greatly surpasses the available supply.
View Article and Find Full Text PDFAssociations between blood donors, component modifications, and the alloimmunization of transfusion recipients.
Transfusion
January 2025
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Background: Prior studies have evaluated transfusion recipient variables impacting red blood cell (RBC) alloimmunization, but few focused on potentially modifiable blood donor or blood component variables.
Study Design And Methods: Data from the Recipient Epidemiology and Donor Evaluation Study (REDS)-III, which links donor, component, and patient data in an integrated database, were accessed. For any given RBC unit with sufficient blood donor and component data, we determined if the transfusion recipient experienced a new RBC alloimmunization event ("case") within 16 weeks of the transfusion or not ("control").
Robust metabolomic age prediction based on a wide selection of metabolites.
J Gerontol A Biol Sci Med Sci
January 2025
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Chronological age is a major risk factor for numerous diseases. However, chronological age does not capture the complex biological aging process. the difference between the chronological age and biologically driven aging could be more informative in reflecting health status.
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