Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity.

Trends Immunol

Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, 94158, USA. Electronic address:

Published: September 2020

Huang et al. have found that deletion of astrocyte lineage-specifying transcription factor NFIA from mature astrocytes alters astrocyte morphology, molecular identity, and synaptic-support capacity in a region-specific manner. We discuss the implications of these findings in light of emerging roles for astrocytes in immune cell crosstalk.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214865PMC
http://dx.doi.org/10.1016/j.it.2020.07.011DOI Listing

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