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Protection against dengue virus requires a sustained balance of antibody and T cell responses. | LitMetric

Protection against dengue virus requires a sustained balance of antibody and T cell responses.

Curr Opin Virol

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA. Electronic address:

Published: August 2020

AI Article Synopsis

Article Abstract

Pre-existing immunity to dengue virus (DENV) can either protect against or exacerbate, a phenomenon known as antibody dependent enhancement (ADE), a secondary DENV infection. DENV, as an escalating health problem worldwide, has increased the urgency to understand the precise parameters shaping the anti-DENV antibody (Ab) and T cell responses, thereby tipping the balance towards protection versus pathogenesis. Herein, we present the current state of knowledge of about the interplay between the Ab and T cell responses that dictate the outcome of DENV infection and discuss how this newfound knowledge is reshaping strategies for developing safe and effective DENV vaccines.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655611PMC
http://dx.doi.org/10.1016/j.coviro.2020.07.018DOI Listing

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