AI Article Synopsis
- A study analyzed the levels of apoE-rich HDL in 113 patients to assess the links between metabolic syndrome (MetS) and HDL cholesterol levels.
- The results showed that participants with MetS had lower apoE-rich HDL cholesterol and a lower ratio of apoE-HDL to total HDL compared to those without MetS.
- Additionally, lower levels of apoE-HDL were associated with higher visceral fat and plasma triglycerides, indicating that apoE-rich HDL might be a helpful marker for understanding MetS and related cardiovascular issues.
Article Abstract
Background: High-density lipoprotein (HDL) containing apolipoprotein E (apoE-rich HDL) represents a small portion of plasma HDL. We recently established a method for measuring plasma apoE-rich HDL. This study aimed to investigate the relationship between metabolic syndrome (MetS) and apoE-rich HDL levels.
Methods: The apoE-rich HDL-cholesterol (HDL-C) levels and metabolic characteristics of 113 patients were analyzed.
Results: The MetS group (n = 58) had significantly lower apoE-rich HDL-C and a lower apoE-rich HDL-C/HDL-C ratio (apoE-HDL (%)) compared to the non-MetS group. The prevalence of MetS was increased when apoE-HDL (%) decreased. In simple regression analyses, apoE-HDL (%) was significantly inversely correlated with visceral fat area (r = -0.370, P < 0.001) and plasma triglycerides (r = -0.447, P < 0.001) and positively correlated with low-density lipoprotein (LDL) mean particle size (r = 0.599, P < 0.001) and HDL mean particle size (r = 0.512, P < 0.001). Stepwise multiple regression analysis revealed that LDL mean particle size, a component of the atherogenic lipoprotein profile, was an independent predictor of apoE-HDL (%) (adjusted R = 0.409).
Conclusions: Plasma apoE-rich HDL levels might be a valuable indicator of MetS. These findings may help further understand HDL subfraction analysis in cardiometabolic diseases.
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| http://dx.doi.org/10.1016/j.cca.2020.08.020 | DOI Listing |
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Article Synopsis
- A study analyzed the levels of apoE-rich HDL in 113 patients to assess the links between metabolic syndrome (MetS) and HDL cholesterol levels.
- The results showed that participants with MetS had lower apoE-rich HDL cholesterol and a lower ratio of apoE-HDL to total HDL compared to those without MetS.
- Additionally, lower levels of apoE-HDL were associated with higher visceral fat and plasma triglycerides, indicating that apoE-rich HDL might be a helpful marker for understanding MetS and related cardiovascular issues.
Transport of Apolipoprotein B-Containing Lipoproteins through Endothelial Cells Is Associated with Apolipoprotein E-Carrying HDL-Like Particle Formation.
Int J Mol Sci
November 2018
Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, TN 37208, USA.
Passage of apolipoprotein B-containing lipoproteins (apoB-LPs), i.e., triglyceride-rich lipoproteins (TRLs), intermediate-density lipoproteins (IDLs), and low-density lipoproteins (LDLs), through the endothelial monolayer occurs in normal and atherosclerotic arteries.
View Article and Find Full Text PDFA rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements.
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Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan. Electronic address:
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