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http://dx.doi.org/10.1111/ijcp.13676 | DOI Listing |
Pharmaceuticals (Basel)
December 2024
Institute of Biomedical Chemistry, Moscow 119121, Russia.
The p53 protein has attracted huge research interest over several decades due to its role as one of the most important tumor suppressors in mammals, which orchestrates a synchronous response from normal cells in the body to various forms of stress. The diverse cellular activities of the p53 protein are regulated mainly via its post-translational modifications (PTMs). PTMs affect p53 on several levels: at the level of the assembly of tetrameric complexes on DNA to transactivate its target genes, at the level of the assembly of tetrameric complexes on DNA to transactivate its target genes; at the level of proteolysis in the absence of stress; and on the contrary, at the level of augmented protein stability in response to stress signals.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
Background: Visual impairment can significantly impact an individual's daily activities. Patients require regular monitoring, typically occurring within hospital eye services. Capacity constraints have necessitated innovative solutions to improve patient care.
View Article and Find Full Text PDFProblemThe U.S. physician scholar workforce, currently comprising less than 1.
View Article and Find Full Text PDFJ Clin Orthop Trauma
January 2025
Resident, Department of Community Medicine, Mahatma Gandhi Medical College and Research Institute, SBVU (Deemed to be University), Pondicherry, India.
Introduction: Osteoporosis is a silent disease that is more prevalent among postmenopausal women (PMW) due to hormonal transition. Various toolkits, including the Osteoporosis Knowledge Assessment Tool (OKAT), were available for the knowledge assessment. The Osteoporosis-related knowledge is crucial for preventing osteoporosis, but there is no validated, reliable questionnaire in Tamil to measure this knowledge.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Institute of Industrial Science, The University of Tokyo, Meguro, Tokyo, 153-8505, Japan.
Microelectrode array (MEA) techniques provide a powerful method for exploration of neural network dynamics. A critical challenge is to interface 3D neural tissues including neural organoids with the flat MEAs surface, as it is essential to place neurons near to the electrodes for recording weak extracellular signals of neurons. To enhance performance of MEAs, most research have focused on improving their surface treatment, while little attention has been given to improve the tissue-MEA interactions from the medium side.
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