AI Article Synopsis
- - The study investigates the expression of a specific gene related to inflammation during Clostridium difficile infection (CDI), examining a group of 55 adults, including 27 CDI patients and 28 healthy individuals.
- - Results showed that CDI patients had higher white blood cell counts and C-reactive protein levels but lower albumin levels compared to healthy controls, indicating an inflammatory response.
- - The gene expression was significantly lower in CDI patients and inversely correlated with CRP levels, suggesting that reduced gene expression might indicate a weakened ability to combat the infection.
Article Abstract
Cytokines are mediators of inflammation induced in the course of infection (CDI). High Mobility Group Box 1 (HMGB1) is a cytokine playing an important role in the pathogenesis of numerous inflammatory and autoimmune diseases. The aim of the study was to assess the gene expression in the course of CDI. We have performed a prospective case-control study- including 55 adult patients, among them 27 with CDI, who were hospitalized from October 2018 to February 2020 and 28 healthy volunteers. We assessed: a complete blood count with differential leukocyte count, blood creatinine, albumin, and C-reactive protein (CRP) levels. Then, the expression of the gene was evaluated using quantitative Real-Time PCR. Patients with CDI were found to have a significant increase in white blood cells (WBC), neutrophil count, and CRP levels, they also exhibited decreased levels of albumin compared with controls. The gene expression was significantly lower among patients with CDI compared with the control group and significantly, inversely correlated with CRP level in blood. In conclusion, we have observed a decreased expression of the gene in peripheral blood of patients with mild or moderate CDI, which hypothetically could reflect their diminished capability to fight the pathogen.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464922 | PMC |
| http://dx.doi.org/10.3390/microorganisms8081217 | DOI Listing |
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