AI Article Synopsis
- The review highlights the biochemical basis for low-carbohydrate and ketogenic diets (LC/KD) and explains their effectiveness in weight loss and diabetes management.
- Research shows that LC/KD often outperforms other diets and certain medications, leading to remission or reversal of type 2 diabetes, and reducing medication need in many cases.
- Despite strong evidence supporting LC/KD, the approach faces resistance and limited acceptance in clinical practice, posing a challenge to align medical practices with current scientific findings.
Article Abstract
Purpose Of Review: To summarize the underlying biochemical basis for low-carbohydrate and ketogenic diets (LC/KD) and provide mechanisms to account for demonstrated effectiveness.
Recent Findings: LC/KD continue to have success, to outperform other diets as well as most drugs for weight loss and diabetes treatment. In many cases, LC/KD can effect remission (absence of drugs) or reversal (only metformin or nondiabetes drugs) of type 2 diabetes and can provide a significant adjunct to pharmacology in type 1. Medication is reduced or eliminated in most cases. The results are consistent with the biochemical rationale which stresses the global effects of the glucose-insulin axis.
Summary: Evidence for the superior effectiveness of LC/KD for metabolic disease is now overwhelming. At the same time, the approach has received only limited support, and in many cases, persistence of the traditional opposition. Clinical practice or research must confront this crisis in order to bring practice in line with current science and to avoid continued harm to medicine and ultimately, the patient.
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| http://dx.doi.org/10.1097/MED.0000000000000575 | DOI Listing |
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