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http://dx.doi.org/10.1097/00007890-198803000-00029 | DOI Listing |
Arch Dermatol Res
January 2025
Lűbeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Background: A low risk of cardiovascular and metabolic outcomes was found in the randomized clinical trials of dupilumab in atopic dermatitis (AD). Dupilumab-associated real-life long-term cardiometabolic risk relative to other systemic agents is yet to be precisely investigated.
Objective: To assess the risk of cardiometabolic outcomes in patients with AD treated with dupilumab relative to those treated with methotrexate and cyclosporine.
Iran J Pharm Res
September 2024
Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Calcineurin inhibitors and mammalian target of rapamycin (mTOR) inhibitors are essential for maintaining transplanted organs. However, determining the appropriate dosage and predicting blood concentrations of these drugs based solely on net body weight may be inadequate. Previous studies have presented contradictory results regarding the impact of obesity on drug concentrations and transplant success.
View Article and Find Full Text PDFAnn Med Surg (Lond)
October 2024
Department of Dermatology and Venereology, Aleppo University Hospital, University of Aleppo.
Pharmacol Res
October 2024
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Recent advancements in immunology and islet biology have unveiled remarkable prospects for the postponement of Type 1 diabetes (T1D) through the strategic modulation of the immune system. In this Perspective, we discuss the pharmaceutical strides achieved, traversing from pre-clinical validation to the execution of impactful clinical trials. We begin with the initial investigations involving cyclosporine and glucocorticoids in rodent models, such as the non-obese diabetic (NOD) mouse, which guided early clinical trials.
View Article and Find Full Text PDFDermatol Ther (Heidelb)
August 2024
Department of Dermatology, Drug Hypersensitivity, Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, No. 5, Fuxing St, Guishan District, Taoyuan, 333, Taiwan.
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