In a cross-sectional study, one computes the association between exposures (in this case e-cigarette and cigarette use) and an outcome (in this case having had an acute myocardial infarction) among data observed at a fixed point in time. In this case the specific issue is whether the myocardial infarctions may have occurred before e-cigarette use. Rodu & Plurphanswat provided an alternative analysis of the Population Assessment of Tobacco and Health (PATH) data set to one we published, that found an association between having had a myocardial infarction and e-cigarette use. Their analysis selectively changes data for e-cigarette users who started using e-cigarettes before their myocardial infarction, which is inappropriate in a cross-sectional study. Their inappropriate analysis led to the biologically implausible result that non-daily e-cigarette use was protective against myocardial infarction. A standard cross-sectional analysis that treats all exposure groups the same is the appropriate way to do such studies.
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| http://dx.doi.org/10.1111/add.15103 | DOI Listing |
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