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Article Synopsis
  • Maternal exposure to per- and polyfluoroalkyl substances (PFAS) during pregnancy may increase the risk of chromosomal abnormalities in offspring, based on recent experimental and epidemiological evidence.
  • A study using data from the Japan Environment and Children's Study found 44 cases of chromosomal abnormalities in over 24,000 births, with certain PFAS like PFNA and PFOS showing strong associations with these abnormalities.
  • The analysis indicated that a doubling of PFAS concentrations, particularly PFOS, was significantly linked to chromosomal issues, highlighting concerns about environmental exposure implications for fetal health.
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Adsorption of per- and poly-fluoroalkyl substances (PFAS) on Ni: A DFT investigation.

Chemosphere

June 2024

Department of Civil, Materials, and Environmental Engineering, University of Illinois Chicago, USA. Electronic address:

Electrocatalytic destruction of per- and polyfluoroalkyl substances (PFAS) is an emerging approach for treatment of PFAS-contaminated water. In this study, a systematic ab initio investigation of PFAS adsorption on Ni, a widely used electrocatalyst, was conducted by means of dispersion-corrected Density Functional Theory (DFT) calculations. The objective of this investigation was to elucidate the adsorption characteristics and charge transfer mechanisms of different PFAS molecules on Ni surfaces.

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Elevated levels of serum per- and poly-fluoroalkyl substances (PFAS) in contact lens users of U.S. young adults.

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February 2024

Institute of Health Sciences, Korea University College of Health Science, Seoul, South Korea; School of Health and Environmental Science, Korea University College of Health Science, Seoul, South Korea. Electronic address:

Despite evidence indicating the presence of per- and poly-fluoroalkyl substances (PFAS) in contact lenses (CL), it remains unclear whether CL use increases PFAS exposure in the general population. We aimed to determine whether CL users have higher serum concentrations of PFAS than non-users, using data of 1660 adults aged 20-39 years participating in the National Health and Nutrition Examination Survey 1999-2000 and 2003-2008. We classified the individuals into CL users and non-users using the record of vision correction types during a vision test.

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A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate.

Environ Int

October 2023

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. Electronic address:

Background: Exposures to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), environmentally persistent chemicals detectable in the blood of most Americans, have been associated with several health outcomes. To offer insight into their possible biologic effects, we evaluated the metabolomic correlates of circulating PFOS and PFOA among 3,647 participants in eight nested case-control serum metabolomic profiling studies from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Methods: Metabolomic profiling was conducted by Metabolon Inc.

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Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood.

Environ Res

June 2023

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark.

Background: Exposure to perfluoroalkyl substances (PFAS) has been associated with changes in insulin sensitivity and pancreatic beta-cell function in humans. Genetic predisposition to diabetes may modify these associations; however, this hypothesis has not been yet studied.

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