In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478726 | PMC |
| http://dx.doi.org/10.1084/jem.20200831 | DOI Listing |
Publication Analysis
Top Keywords
allelic exclusion
8
rsss set
4
set odds
4
odds exclusion
4
exclusion issue
4
issue jem
4
jem https//doiorg/101084/jem20200412
4
https//doiorg/101084/jem20200412 provide
4
provide insights
4
insights allelic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!