To date, reliable tests enabling the identification of celiac disease (CD) patients at a greater risk of developing poly-autoimmune diseases are not yet available. We therefore aimed to identify non-invasive microbial biomarkers, useful to implement diagnosis of poly-autoimmunity. Twenty CD patients with poly-autoimmunity (cases) and 30 matched subjects affected exclusively by CD (controls) were selected. All patients followed a varied gluten-free diet for at least 1 year. Fecal microbiota composition was characterized using bacterial 16S ribosomal RNA gene sequencing. Significant differences in gut microbiota composition between CD patients with and without poly-autoimmune disease were found using the edgeR algorithm. Spearman correlations between gut microbiota and clinical, demographic, and anthropometric data were also examined. A significant reduction of , and abundances was found in CD patients with poly-autoimmunity compared to the controls. was specifically reduced in CD patients with Hashimoto's thyroiditis and its abundance correlated negatively with abdominal circumference values in patients affected exclusively by CD. In addition, the duration of CD correlated with the abundance of Firmicutes (negatively) and (positively), whereas the abundance of correlated positively with the duration of poly-autoimmunity. This study provides supportive evidence that specific variations of gut microbial taxa occur in CD patients with poly-autoimmune diseases. These findings open the way to future validation studies on larger cohorts, which might in turn lead to promising diagnostic applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390951 | PMC |
| http://dx.doi.org/10.3389/fcimb.2020.00349 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of thyroid dysfunction in childhood-onset systemic lupus erythematosus: Risk factors for Hashimoto's thyroiditis.
Lupus
October 2024
Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Objective: Increased frequency of autoimmune thyroid disease, particularly Hashimoto's thyroiditis (HT) was reported several studies in the literature, in individuals with childhood-onset systemic lupus erythematosus (cSLE). Our study aimed to investigate the prevalence and contributing factors of thyroid dysfunction and HT among cSLE patients.
Methods: Thyroid function tests were obtained cross-sectionally from cSLE patients.
CD20 + T lymphocytes in isolated Hashimoto's thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study.
J Endocrinol Invest
November 2024
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Article Synopsis
- CD20 T cells, making up about 5% of T lymphocytes, are linked to higher production of inflammatory cytokines IL-17A and IFN-γ, and may contribute to autoimmune disorders, especially Hashimoto's thyroiditis (HT) in this study.
- The research involved 65 HT patients—some with only HT and others with associated disorders, plus 20 healthy donors as a control group, using blood samples analyzed with flow cytometry to study CD20 T cell behavior.
- Results indicated that CD20 T cell percentages were notably higher in autoimmune patients compared to healthy individuals, particularly in those with associated chronic atrophic gastritis, suggesting a potential role in
A Case Report of Autoimmune Phenomena With Underlying Breast Cancer: Occam's Razor Versus Hickam's Dictum.
Cureus
May 2022
Medicine and Endocrinology, State University of New York Downstate Medical Center, Brooklyn, USA.
The association between malignancies and autoimmunity had been well-established. The proposed pathophysiology and causality can be bidirectional. For example, a paraneoplastic syndrome can be triggered by an underlying malignancy or vice versa, where chronic inflammation of organs affected by autoimmunity can induce malignant transformation such as the case with inflammatory bowel disease and colorectal cancer or primary sclerosing cholangitis and hepatobiliary cancer.
View Article and Find Full Text PDFSTAT3-confusion-of-function: Beyond the loss and gain dualism.
J Allergy Clin Immunol
November 2022
Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Background: Germline mutations of signal transducer and activator of transcription 3 (STAT3) are responsible for 2 distinct human diseases: autosomal-dominant hyper-IgE syndrome (AD-HIES) caused by STAT3 loss-of-function mutations and STAT3 gain-of-function disease. So far, these entities have been regarded as antithetic, with AD-HIES mainly associated with characteristic infections and a connective tissue phenotype and STAT3 gain-of-function characterized by lymphoproliferation and poly-autoimmunity. The R335W substitution in the DNA-binding domain of STAT3 was initially described in 2 patients with typical AD-HIES, but paradoxically, recent functional analysis demonstrated a gain-of-function effect of this variant.
View Article and Find Full Text PDFMultiple Sclerosis and Autoimmunity: A Veiled Relationship.
Cureus
April 2022
Medicine, Bogomolets National Medical University, Kiev, UKR.
Multiple sclerosis (MS) is an autoimmune inflammatory illness that affects the central nervous system (CNS) when the body's immune system attacks its tissue. It is characterized by demyelination and varying degrees of axonal loss. This article has compiled various studies elaborating MS and other autoimmune diseases (ADs) co-occurrence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!