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Protein-coated corrole nanoparticles for the treatment of prostate cancer cells. | LitMetric

AI Article Synopsis

  • Development of new therapies to eliminate malignant tumors is crucial in cancer research.
  • A study introduced corrole-protein nanoparticles (NPs) coated with human serum albumin, which showed effectiveness against prostate cancer cells.
  • These nanoparticles were found to enter cells quickly and cause cell death through mechanisms that disrupt cellular balance and produce reactive oxygen species.

Article Abstract

Development of novel therapeutic strategies to eradicate malignant tumors is of paramount importance in cancer research. In a recent study, we have introduced a facile protocol for the preparation of corrole-protein nanoparticles (NPs). These NPs consist of a corrole-core coated with protein. We now report that a novel lipophilic corrole, ()Ga, delivered as human serum albumin (HSA)-coated NPs, displayed antineoplastic activity towards human prostate cancer DU-145 cells. Cryo-TEM analysis of these NPs revealed an average diameter of 50.2 ± 8.1 nm with a spherical architecture exhibiting low polydispersity. In vitro cellular uptake of ()Ga/albumin NPs was attributable to rapid internalization of the corrole through ligand binding-dependent extracellular release and intercalation of the corrole cargo into the lipid bilayer of the plasma membrane. This finding is in contrast with a previously reported study on corrole-protein NPs that displayed cellular uptake via endocytosis. Investigation of the non-light-induced mechanism of action of ()Ga suggested the induction of necrosis through plasma membrane destabilization, impairment of calcium homeostasis, lysosomal stress and rupture, as well as formation of reactive oxygen species (ROS). ()Ga also exhibited potent light-induced cytotoxicity through ROS generation. These findings demonstrate a rapid cellular uptake of ()Ga/protein NPs along with targeted induction of tumor cell necrosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387447PMC
http://dx.doi.org/10.1038/s41420-020-0288-xDOI Listing

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