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Signaling pathways play key roles in many important biological processes such as cell division, differentiation, and migration. Phosphorylation site-specific antibodies specifically target proteins phosphorylated on a given tyrosine, threonine, or serine residue. Use of phospho-specific antibodies facilitates analysis of signaling pathway regulation and activity.
View Article and Find Full Text PDFUnveiling novel antimicrobial peptides from the ruminant gastrointestinal microbiomes: A deep learning-driven approach yields an anti-MRSA candidate.
J Adv Res
January 2025
Ruminant Nutrition and Feed Engineering Technology Research Center, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China; Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research on Animal Gut Nutrition, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. Electronic address:
Introduction: Antimicrobial peptides (AMPs) present a promising avenue to combat the growing threat of antibiotic resistance. The ruminant gastrointestinal microbiome serves as a unique ecosystem that offers untapped potential for AMP discovery.
Objectives: The aims of this study are to develop an effective methodology for the identification of novel AMPs from ruminant gastrointestinal microbiomes, followed by evaluating their antimicrobial efficacy and elucidating the mechanisms underlying their activity.
Untapped Resources? Engaging Junior Faculty with Advanced Career Training in Near-Peer Mentoring to Build Professional Identity.
South Med J
January 2025
From the Department of Internal Medicine, Division of General Internal Medicine, Emory University School of Medicine, and Grady Memorial Hospital, Atlanta, Georgia.
Effective early mentoring is essential for propelling academic careers. There is a growing cohort of junior faculty with advanced skills in medical education and research; these individuals need both mentoring and the opportunity to take on mentorship roles. Generalists who pursue advanced training in medical education or clinical research often enter junior faculty positions alongside recent residency graduates, leaving their skillset untapped.
View Article and Find Full Text PDFIncidental iron oxide nanoclusters drive confined Fenton-like detoxification of solid wastes towards sustainable resource recovery.
Nat Commun
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing, 210023, PR China.
The unique properties of nanomaterials offer vast opportunities to advance sustainable processes. Incidental nanoparticles (INPs) represent a significant part of nanomaterials, yet their potential for sustainable applications remains largely untapped. Herein, we developed a simple strategy to harness INPs to upgrade the waste-to-resource paradigm, significantly reducing the energy consumption and greenhouse gas emissions.
View Article and Find Full Text PDFBeyond despair: Leveraging ecosystem restoration for psychosocial resilience.
Proc Natl Acad Sci U S A
January 2025
Division of Marine Science and Conservation, Nicholas School of the Environment, Duke University Marine Lab, Beaufort, NC 28516.
Ecosystem restoration has historically been viewed as an ecological endeavor, but restoration possesses significant, yet largely untapped, potential as a catalyst for personal and social transformation. We highlight the opportunity for restoration to enhance community resilience by increasing agency and collective action and countering the pervasive perception that we are powerless witnesses to environmental decline. In this perspective, we take a "bright spots" approach and highlight successful examples of ecosystem restoration that have helped to nurture a sense of place, foster optimism, and cultivate stronger and more diverse social networks.
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