(Bezdenko) are egg parasitoids that are used throughout the world as biological control agents and in laboratories as model species. Despite this ubiquity, few genetic resources exist beyond COI, ITS2, and RAPD markers. Aided by a infection, a wild-caught strain from Germany was reared for low heterozygosity and sequenced in a hybrid strategy, after which several assembling strategies were evaluated. The best assembly, derived from a DBG2OLC-based pipeline, yielded a genome of 235 Mbp made up of 1,572 contigs with an N50 of 556,663 bp. Following a rigorous -, homology-, and evidence-based annotation, 16,905 genes were annotated and functionally described. As an example of the utility of the genome, a simple ortholog cluster analysis was performed with sister species , revealing over 6000 shared clusters and under 400 clusters unique to each species. The genome and transcriptome presented here provides an essential resource for comparative genomics of the commercially relevant genus , but also for research into molecular evolution, ecology, and breeding of .
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http://dx.doi.org/10.1534/g3.120.401344 | DOI Listing |
J Nat Prod
November 2024
Pharmacognosy Institute and Department of Pharmaceutical Sciences, University of Illinois Chicago College of Pharmacy, 833 S. Wood Street, Chicago, Illinois 60612, United States.
medRxiv
October 2024
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
IEEE J Biomed Health Inform
October 2024
Automatic extraction of valuable, structured evidence from the exponentially growing clinical trial literature can help physicians practice evidence-based medicine quickly and accurately. However, current research on evidence extraction has been limited by the lack of generalization ability on various clinical topics and the high cost of manual annotation. In this work, we address these challenges by constructing a PICO-based evidence dataset PICO-DS, covering five clinical topics.
View Article and Find Full Text PDFJ Dent Res
November 2024
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Current interventions for oral/dental diseases heavily rely on operative/surgical procedures, while the discovery of novel drug targets may enable access to noninvasive pharmacotherapy. Therefore, this study aims to leverage large-scale data and Mendelian randomization (MR) techniques, utilizing genetic variants as instruments, to identify potential therapeutic targets for oral and dental diseases supported by genetic evidence. By intersecting 4,302 druggable genes with expression quantitative trait loci from 31,684 blood samples, we identified 2,580 druggable targets as exposures.
View Article and Find Full Text PDFPlant Cell Rep
October 2024
School of Biology & Environmental Science, University College Dublin, Belfield, Dublin, Ireland.
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