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Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA. Electronic address:
Published: November 2020
AI Article Synopsis
Over 44 million people globally have Alzheimer's disease (AD), which is often linked to disrupted sleep patterns.
Many adults report getting less than 7 hours of sleep per night, which is crucial for mental and physical health.
Research on C57BL/6 mice showed that chronic sleep loss can lead to cognitive impairment and increased levels of amyloid-beta in the hippocampus, suggesting that insufficient sleep negatively affects cognitive function.
Article Abstract
Currently, over 44 million people worldwide suffer from Alzheimer's disease (AD). A common feature of AD is disrupted sleep. Sleep is essential for many psychological and physiological functions, though 35.3% of adults report getting less than 7 hours per night. The present research examined whether chronic sleep restriction would elevate hippocampal amyloid-beta expression or alter cognitive ability in adult C57BL/6 mice. Chronic sleep restriction was associated with cognitive impairment and increased hippocampal amyloid-beta. Thus, chronic sleep loss may have a detrimental effect upon cognitive function, in part, via increasing amyloid-beta levels in the hippocampus, even in non-genetically modified mice.
