How the replisome senses and deals with DNA secondary structures has been a mystery. A new study from the Sale and Pellegrini laboratories finds that the Timeless protein has a G-quadruplex binding domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507315 | PMC |
| http://dx.doi.org/10.15252/embj.2020106305 | DOI Listing |
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