AI Article Synopsis
- The study highlights the use of fluorine (F) magnetic resonance (MR) detection combined with inorganic probes for biological research.
- Two novel inorganic probes are introduced that switch from a low-spin to high-spin state under specific conditions, allowing for effective MR sensing.
- This spin-state change enables the detection of light or enzymes in live cells through distinctive signals, showcasing the potential for broad applications in biosensing with F MR technology.
Article Abstract
F magnetic resonance (MR) based detection coupled with well-designed inorganic systems shows promise in biological investigations. Two proof-of-concept inorganic probes that exploit a novel mechanism for F MR sensing based on converting from low-spin (S=0) to high-spin (S=1) Ni are reported. Activation of diamagnetic NiL and NiL by light or β-galactosidase, respectively, converts them into paramagnetic NiL , which displays a single F NMR peak shifted by >35 ppm with accelerated relaxation rates. This spin-state switch is effective for sensing light or enzyme expression in live cells using F MR spectroscopy and imaging that differentiate signals based on chemical shift and relaxation times. This general inorganic scaffold has potential for developing agents that can sense analytes ranging from ions to enzymes, opening up diverse possibilities for F MR based biosensing.
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| http://dx.doi.org/10.1002/anie.202010587 | DOI Listing |
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