This study examined interrelationships among insomnia, stress, anxiety, and metabolic risk factors. : A total of 124 college students were included in the analysis (age = 21 ± 1 years). Insomnia, stress of life events, and anxiety were assessed using self-reported questionnaires. Fasting blood samples were assayed for glucose, insulin, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-cholesterol), and low-density lipoprotein cholesterol (LDL-cholesterol). : Insomnia was positively associated with stress of life events (β = 0.28, < .001) and anxiety (β = 0.46, < .001). Insomnia was related to elevated fasting insulin (β = 0.12, = .04) and triglyceride level (β = 1.85, < .001). An inverse association was found between insomnia and HDL-cholesterol (β = -0.45, = .03). Sobel's test for mediation showed that stress of life events ( = .020) and anxiety ( = .013) mediated the relationship between insomnia and hypertriglyceridemia. : Reducing stress and anxiety among college students with insomnia may influence subsequent cardiovascular health.
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