This study reports the first total synthesis of the bioactive oxepinochromones 12--acetyleranthin () (angular isomer) and 12--acetylptaeroxylinol () (linear isomer). The antifungal activity of these compounds and their derivatives was determined against and . Most compounds had good selectivity between the two fungi and showed moderate to good activity. 12--Acetyleranthin () had the highest activity against , with an MIC value of 9.9 μM, while 12--acetylptaeroxylinol (), the compound present in , had the highest activity against , with an MIC value of 4.9 μM.
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