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Constructing Meaningful Careers for All: Building an Evidence-Informed Conceptual Framework for Faculty Development on a Foundation of Fulfillment.
J Contin Educ Health Prof
March 2025
Dr. Susan Kuhn: Associate Professor, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada; Dr. Lorelli Nowell: Associate Professor, Faculty of Nursing, University of Calgary, Calgary, Canada; Dr. Chantelle Barnard: Clinical Assistant Professor, Department of Pediatrics, Cumming School of Medicine, Calgary, Canada; Dr. Elizabeth Oddone Paolucci: Professor, Departments of Community Health Sciences and Surgery, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Faculty development programs are an important part of career building and professional fulfillment for health professionals. A framework that addresses the centrality of fulfillment at work for diverse medical careers is lacking, yet necessary, for faculty development programs to have a comprehensive positive impact. A conceptual framework for faculty development to support meaningful careers for all individuals was, therefore, constructed through an exploration of the literature on professional fulfillment, career planning, and development across career paths, stages, and identity groups, as well as forms of professional career support such as mentoring.
View Article and Find Full Text PDFAddressing health equity during design and implementation of health system reform initiatives: a scoping review and framework.
Int J Equity Health
March 2025
The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Background: Health equity is a commonly asserted goal of health systems. However, there is a limited understanding on how best to promote equity as a part of health system reform initiatives. We conducted a scoping review to (1) identify and characterise strategies that promote health equity during the design and implementation of health system reform initiatives; and (2) determine opportunities to strengthen health equity informed policy design and implementation processes and outcomes.
View Article and Find Full Text PDFMotor preparation tracks decision boundary crossing rather than accumulated evidence in temporal decision-making.
J Neurosci
March 2025
Department of Psychology, Hebrew University of Jerusalem, Mt. Scopus, Jerusalem 9190501, Israel.
Interval timing, the ability of animals to estimate the passage of time, is thought to involve diverse neural processes rather than a single central "clock" (Paton & Buonomano, 2018). Each of the different processes engaged in interval timing follows a different dynamic path, according to its specific function. For example, attention tracks anticipated events, such as offsets of intervals (Rohenkohl & Nobre, 2011), while motor processes control the timing of the behavioral output (De Lafuente et al.
View Article and Find Full Text PDFT Cell Development: From T-Lineage Specification to Intrathymic Maturation.
Adv Exp Med Biol
March 2025
Department of Immunology, University of Toronto & Sunnybrook Research Institute, Toronto, ON, Canada.
T cell development occurs in the thymus in both mice and humans. Upon entry into the thymus, bone marrow-derived blood-borne progenitors receive instructive signals, including Notch signaling, to eliminate their potential to develop into alternative immune lineages while committing to the T cell fate. Upon T-lineage commitment, developing T cells receive further instructional cues to generate different T cell sublineages, which together possess diverse immunological functions to provide host immunity.
View Article and Find Full Text PDFSingle-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells.
Elife
March 2025
Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, United States.
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic fate in response to sex-determining cues from the fetal gonad. The critical processes required for PGCs to integrate and respond to signals from the somatic environment in gonads are not well understood.
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