Chickpea production is constrained worldwide by the necrotrophic fungal pathogen , the causal agent of Ascochyta blight (AB). To reduce the impact of this disease, novel sources of resistance are required in chickpea cultivars. Here, we screened a new collection of wild accessions for AB resistance and identified accessions resistant to multiple, highly pathogenic isolates. In addition to this, analyses demonstrated that some collection sites of harbor predominantly resistant accessions, knowledge that can inform future collection missions. Furthermore, a genome-wide association study identified regions of the genome associated with AB resistance and investigation of these regions identified candidate resistance genes. Taken together, these results can be utilized to enhance the resistance of chickpea cultivars to this globally yield-limiting disease.
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http://dx.doi.org/10.1094/PHYTO-04-20-0137-R | DOI Listing |
Pharmaceutics
January 2025
Medical Faculty Heidelberg, Heidelberg University, 69117 Heidelberg, Germany.
: Bempedoic acid (BA) is a novel cholesterol-lowering agent with proven positive effects on cardiovascular endpoints. Because it is an inhibitor of the hepatic transporters OATP1B1 and OATP1B3, two uptake transporters regulating the intrahepatic availability of statins, it increases the systemic exposure of co-administered statins. This interaction could raise the risk of myopathy.
View Article and Find Full Text PDFNutrients
January 2025
Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
There is a pressing need to expand the production and consumption of alternative protein sources from plants, fungi, insects, and algae from both nutritional and sustainability perspectives. It is well known that the postprandial rise in plasma amino acid concentrations and subsequent muscle anabolic response is greater after the ingestion of animal-derived protein sources, such as dairy, meat, and eggs, than plant-based proteins. However, emerging evidence shows that a similar muscle anabolic response is observed-despite a lower and slower postprandial aminoacidemia-after the ingestion of alternative protein sources compared with animal-derived protein sources.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Background: Abel () is widely cultivated and serves as an important source of edible oil. Yet, during oil production, pruned branches generate significant waste and contribute to environmental pollution.
Objectives: In this work, we obtain a natural polysaccharide from the branches of and optimize its extraction using Box-Behnken design (BBD), which is a statistical method commonly used in response surface methodology.
Pharmaceuticals (Basel)
December 2024
Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, TR-03100 Afyonkarahisar, Turkey.
: L. is a genus of the Fabaceae family, encompassing over 3000 species globally, with 380 species found in Turkey. This is the inaugural examination of the phytochemical, antioxidant, antibacterial, and cytotoxic properties of .
View Article and Find Full Text PDFSensors (Basel)
January 2025
College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou 310027, China.
Domain-generalizable re-identification (DG Re-ID) aims to train a model on one or more source domains and evaluate its performance on unseen target domains, a task that has attracted growing attention due to its practical relevance. While numerous methods have been proposed, most rely on discriminative or contrastive learning frameworks to learn generalizable feature representations. However, these approaches often fail to mitigate shortcut learning, leading to suboptimal performance.
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