New phenylpropanoids from the fruits of and their anti-inflammatory activity.

Seven new phenylpropanoids, including two pairs of enantiomers of 8--4'-type neolignans, named (±)-xanthiifructins A-B (-), a pair of simple phenylpropanoid derivatives (±)-xanthiifructins C (), and a racemic phenylpropanoid derivative xanthiifructin D (), together with four known analogues (-) were isolated from the fruits of . Racemic xanthiifructins A-C were separated on chiral HPLC columns. Their structures were elucidated by comprehensive spectroscopic data analysis and comparison with the literatures. The anti-inflammatory and cytotoxic activities were evaluated for all isolates. Among them, (-)-xanthiifructin C () exhibited potent inhibitory effect against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with an IC value of 9.94 ± 0.57 μM. All compounds obviously were inactive for three human tumor cell lines (MCF-7, HepG2, and A549) with IC values much more than 10 μM.